Article

SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells

2026-04-13

Abstract excerpt

Peroxisome proliferator-activated receptor gamma (PPARγ) is a key transcriptional regulator of genes mediating adipogenesis (fat-cell differentiation) and lipid storage in several cell types like hepatocytes. As such, its regulation is crucial for cell and organismal physiology. Indeed, PPARγ’s activity is regulated by multiple mechanisms, including post-transcriptional modifications, which, when dys-coordinated,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2135e335-b8dc-5e3a-9195-0c2c72d93df4
DOI: 10.64898/2026.04.10.717761

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cellsDOI 10.64898/2026.04.10.717761Read

Genetic and epigenetic regulation of PPARγ during adipogenesis.Semantic proximity Read

Peroxisome Proliferator-Activated Receptor-γ as a Target and Regulator of Epigenetic Mechanisms in Nonalcoholic Fatty Liver DiseaseSemantic proximity Read

Maternal palmitic acid overload establishes a SETD1A-dependent epigenetic memory that programs offspring susceptibility to metabolic liver diseaseSemantic proximity Read

Thiol methyltransferase METTL7B coordinates lipid metabolism and promotes tumor progression in pancreatic cancerSemantic proximity Read

METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs.Semantic proximity Read

The Functional Interaction Between PRDM16 and the SREBP Pathway Controls Lipid MetabolismSemantic proximity Read

Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD)Semantic proximity Read

Histone Succinylation-Driven LINE-1 Reactivation Links High-Fat Diet Stress to Hepatic Inflammation and Liver DiseaseSemantic proximity Read

DNA Methylation Modulates Aging Process in AdipocytesSemantic proximity Read

RBM15 suppresses hepatic insulin sensitivity of offspring of Gestational Diabetes Mellitus Mice via m6A-mediated regulation of CLDN4Semantic proximity Read

m <sup>6</sup> A Regulates Liver Metabolic Disorders and Hepatogenous DiabetesSemantic proximity Read

Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctionsSemantic proximity Read