Article
Structural basis for dual roles of Aar2p in U5 snRNP assembly.
Genes & development - 1 Mar 2013
Weber Gert, Cristão Vanessa F, Santos Karine F, Jovin Sina Mozaffari, Heroven Anna C, Holton Nicole, Lührmann Reinhard, Beggs Jean D, Wahl Markus C
Abstract excerpt
Yeast U5 small nuclear ribonucleoprotein particle (snRNP) is assembled via a cytoplasmic precursor that contains the U5-specific Prp8 protein but lacks the U5-specific Brr2 helicase. Instead, pre-U5 snRNP includes the Aar2 protein not found in mature U5 snRNP or spliceosomes. Aar2p and Brr2p bind competitively to a C-terminal region of Prp8p that comprises consecutive RNase H-like and Jab1/MPN-like domains. To...
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