Article
Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation.
Scientific reports - 8 Sept 2015
Mizuno Seiya, Takami Kohei, Daitoku Yoko, Tanimoto Yoko, Dinh Tra Thi Huong, Mizuno-Iijima Saori, Hasegawa Yoshikazu, Takahashi Satoru, Sugiyama Fumihiro, Yagami Ken-ichi
Abstract excerpt
We found a novel spontaneous mouse mutant with depigmentation in the ventral body, which we called White Spotting (WS) mouse. Genetic investigation revealed deletion of a > 1.2-Mb genomic region containing nine genes (Kit, Kdr, Srd5a3, Tmeme165, Clock, Pdcl2, Nmu, Exoc1, and Cep135). We designated this mutant allele Kit(WS). Interestingly, homozygous mutants (Kit(WS/WS)) showed a peri-implantation lethal...
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