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Article

L503F variant of carnitine/organic cation transporter 1 efficiently transports metformin and other biguanides.

The Journal of pharmacy and pharmacology - 1 Sept 2016

Futatsugi Azusa, Masuo Yusuke, Kawabata Shiori, Nakamichi Noritaka, Kato Yukio

Abstract excerpt

OBJECTIVES: Carnitine/organic cation transporter 1 (OCTN1) is involved in gastrointestinal absorption and mitochondrial toxicity of biguanides in rodents, but its pharmacokinetic roles in humans are largely unknown. The purpose of this study was to clarify the transport activities of two major OCTN1 variants, L503F and I306T, for gabapentin and three biguanide drugs, metformin, buformin and phenformin. METHODS:...

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Identifiers

PMID: 27350110
DOI: 10.1111/jphp.12574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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