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Article

Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1.

Pharmaceutical research - 1 May 2010

Kato Yukio, Kubo Yoshiyuki, Iwata Daisuke, Kato Sayaka, Sudo Tomohisa, Sugiura Tomoko, Kagaya Takashi, Wakayama Tomohiko, Hirayama Akiyoshi, Sugimoto Masahiro, Sugihara Kazushi, Kaneko Shuichi, Soga Tomoyoshi, Asano Masahide, Tomita Masaru, Matsui Toshiyuki, Wada Morimasa, Tsuji Akira

Abstract excerpt

PURPOSE: Solute carrier OCTN1 (SLC22A4) is an orphan transporter, the physiologically important substrate of which is still unidentified. The aim of the present study was to examine physiological roles of OCTN1. METHODS: We first constructed octn1 gene knockout (octn1 ( -/- )) mice. Metabolome analysis was then performed to identify substrates in vivo. The possible association of the substrate identified with...

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Identifiers

PMID: 20224991
DOI: 10.1007/s11095-010-0076-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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