Article
A de novo silencer causes elimination of MITF-M expression and profound hearing loss in pigs.
BMC biology - 27 Jun 2016
Chen Lei, Guo Weiwei, Ren Lili, Yang Mingyao, Zhao Yaofeng, Guo Zongyi, Yi Haijin, Li Mingzhou, Hu Yiqing, Long Xi, Sun Boyuan, Li Jinxiu, Zhai Suoqiang, Zhang Tinghuan, Tian Shilin, Meng Qingyong, Yu Ning, Zhu Dan, Tang Guoqing, Tang Qianzi, Ren Liming, Liu Ke, Zhang Shihua, Che Tiandong, Yu Zhengquan, Wu Nan, Jing Lan, Zhang Ran, Cong Tao, Chen Siqing, Zhao Yiqiang, Zhang Yue, Bai Xiaoqing, Guo Ying, Zhao Lidong, Zhang Fengming, Zhao Hui, Zhang Liang, Hou Zhaohui, Zhao Jiugang, Li Jianan, Zhang Lijuan, Sun Wei, Zou Xiangang, Wang Tao, Ge Liangpeng, Liu Zuohua, Hu Xiaoxiang, Wang Jingyong, Yang Shiming, Li Ning
Abstract excerpt
BACKGROUND: Genesis of novel gene regulatory modules is largely responsible for morphological and functional evolution. De novo generation of novel cis-regulatory elements (CREs) is much rarer than genomic events that alter existing CREs such as transposition, promoter switching or co-option. Only one case of de novo generation has been reported to date, in fish and without involvement of phenotype alteration....
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