Article

Activating a patient-relevant mutation of a genetically defined heart disease in a humanized pig model

2025-09-26

Abstract excerpt

<title>Abstract</title> <p>Complex diseases such as progressive cardiomyopathies are often insufficiently reflected in small animal and in vitro models. Large animal species such as pigs provide a valuable alternative, but constitutive genetic manipulation (cGM) has not yet been applied to pig in an effective manner, mainly due to biological and logistic limitations. Here, we describe the generation of a novel hu...

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Literature Corpus work: 3e0a3fd7-63ee-56f1-96ea-fb198f1b6983
DOI: 10.21203/rs.3.rs-7194258/v1

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