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Article

L-Tryptophan Production in Escherichia coli Improved by Weakening the Pta-AckA Pathway.

PloS one - 1 Jan 2016

Liu Lina, Duan Xuguo, Wu Jing

Abstract excerpt

Acetate accumulation during the fermentation process of Escherichia coli FB-04, an L-tryptophan production strain, is detrimental to L-tryptophan production. In an initial attempt to reduce acetate formation, the phosphate acetyltransferase gene (pta) from E. coli FB-04 was deleted, forming strain FB-04(Δpta). Unfortunately, FB-04(Δpta) exhibited a growth defect. Therefore, pta was replaced with a pta variant...

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Identifiers

PMID: 27348810
DOI: 10.1371/journal.pone.0158200
PMCID: PMC4922666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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