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Article

Acetate metabolism in a pta mutant of Escherichia coli W3110: importance of maintaining acetyl coenzyme A flux for growth and survival.

Journal of bacteriology - 1 Nov 1999

Chang D E, Shin S, Rhee J S, Pan J G

Abstract excerpt

In order to study the physiological role of acetate metabolism in Escherichia coli, the growth characteristics of an E. coli W3100 pta mutant defective in phosphotransacetylase, the first enzyme of the acetate pathway, were investigated. The pta mutant grown on glucose minimal medium excreted unusual by-products such as pyruvate, D-lactate, and L-glutamate instead of acetate. In an analysis of the sequential...

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Identifiers

PMID: 10542166
DOI: 10.1128/JB.181.21.6656-6663.1999
PMCID: PMC94129

Genes

PTS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Acetate metabolism in a pta mutant of Escherichia coli W3110: importance of maintaining acetyl coenzyme A flux for growth and survival.PMID 10542166Read ↗

An insight into the role of phosphotransacetylase (pta) and the acetate/acetyl-CoA node in Escherichia coli.Semantic proximity Read ↗

Coordinated activation of PTA-ACS and TCA cycles strongly reduces overflow metabolism of acetate in Escherichia coli.Semantic proximity Read ↗

Metabolic flux analysis of Escherichia coli deficient in the acetate production pathway and expressing the Bacillus subtilis acetolactate synthase.Semantic proximity Read ↗

Redistribution of metabolic fluxes in the central aerobic metabolic pathway of E. coli mutant strains with deletion of the ackA-pta and poxB pathways for the synthesis of isoamyl acetate.Semantic proximity Read ↗

Construction of Pta-Ack pathway deletion mutants of Escherichia coli and characteristic growth profiles of the mutants in a rich medium.Semantic proximity Read ↗

Characterization of the acetate-producing pathways in Escherichia coli.Semantic proximity Read ↗

Acetate consumption activity directly determines the level of acetate accumulation during Escherichia coli W3110 growth.Semantic proximity Read ↗

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Comparison of different strategies to reduce acetate formation in Escherichia coli.Semantic proximity Read ↗

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Characterization and evaluation of a pta (phosphotransacetylase) negative mutant of Escherichia coli HB101 as production host of foreign lipase.Semantic proximity Read ↗

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