Metabolic engineering of Escherichia coli for acetaldehyde overproduction using pyruvate decarboxylase from Zymomonas mobilis.

doi:10.1016/j.enzmictec.2017.09.012

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Article

Metabolic engineering of Escherichia coli for acetaldehyde overproduction using pyruvate decarboxylase from Zymomonas mobilis.

Enzyme and microbial technology - 1 Feb 2018

Balagurunathan Balaji, Tan Lily, Zhao Hua

Abstract excerpt

For the sustainable production of acetaldehyde, a key raw-material for a large number of chemical products, microbial production is a promising alternative. We have engineered an Escherichia coli strain for acetaldehyde production from glucose by introducing the pyruvate decarboxylase (Pdc) from Zymomonas mobilis and NADH oxidase (Nox) from Lactococcus lactis. Acetaldehyde production was systematically improved...

Topics

Acetaldehyde
Escherichia coli
Gene Knockout Techniques
Glucose
Lactococcus lactis
Metabolic Engineering
Metabolic Networks and Pathways
Multienzyme Complexes
Mutation
NADH, NADPH Oxidoreductases
Pyruvate Decarboxylase
Zymomonas

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Identifiers

PMID: 29224627
DOI: 10.1016/j.enzmictec.2017.09.012

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