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Article

Decreased DNA Methylation in the Shati/Nat8l Promoter in Both Patients with Schizophrenia and a Methamphetamine-Induced Murine Model of Schizophrenia-Like Phenotype.

PloS one - 1 Jan 2016

Uno Kyosuke, Kikuchi Yuu, Iwata Mina, Uehara Takashi, Matsuoka Tadasu, Sumiyoshi Tomiki, Okamoto Yoshinori, Jinno Hideto, Takada Tatsuyuki, Furukawa-Hibi Yoko, Nabeshima Toshitaka, Miyamoto Yoshiaki, Nitta Atsumi

Abstract excerpt

The number of patients with schizophrenia has increased over the past decade. Previously, many studies have been performed to establish its diagnostic criteria, prophylactic methods, and effective therapies. In this study, we analyzed whether the ratios of DNA methylation in CpG islands of the Shati/Nat8l is decreased in model mice of schizophrenia-like phenotype using genomic DNA collected from brain regions and...

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Identifiers

PMID: 27348532
DOI: 10.1371/journal.pone.0157959
PMCID: PMC4922576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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