Article
DNA methyl transferase (DNMT) gene polymorphisms could be a primary event in epigenetic susceptibility to schizophrenia.
PloS one - 1 Jan 2014
Saradalekshmi Koramannil Radha, Neetha Nanoth Vellichiramal, Sathyan Sanish, Nair Indu V, Nair Chandrasekharan M, Banerjee Moinak
Abstract excerpt
DNA methylation has been implicated in the etiopathology of various complex disorders. DNA methyltransferases are involved in maintaining and establishing new methylation patterns. The aim of the present study was to investigate the inherent genetic variations within DNA methyltransferase genes i...
Topics
- Adult
- DNA (Cytosine-5-)-Methyltransferases
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- India
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Risk Factors
- Schizophrenia
- Sex Factors