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Article

The tumoral A genotype of the MGMT rs34180180 single-nucleotide polymorphism in aggressive gliomas is associated with shorter patients' survival.

Carcinogenesis - 1 Feb 2016

Fogli Anne, Chautard Emmanuel, Vaurs-Barrière Catherine, Pereira Bruno, Müller-Barthélémy Mélanie, Court Franck, Biau Julian, Pinto Afonso Almeida, Kémény Jean-Louis, Khalil Toufic, Karayan-Tapon Lucie, Verrelle Pierre, Costa Bruno Marques, Arnaud Philippe

Abstract excerpt

Malignant gliomas are the most common primary brain tumors. Grade III and IV gliomas harboring wild-type IDH1/2 are the most aggressive. In addition to surgery and radiotherapy, concomitant and adjuvant chemotherapy with temozolomide (TMZ) significantly improves overall survival (OS). The methylation status of the O(6)-methylguanine-DNA methyltransferase (MGMT) promoter is predictive of TMZ response and a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26717998
DOI: 10.1093/carcin/bgv251

Genes

MGMT
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The tumoral A genotype of the MGMT rs34180180 single-nucleotide polymorphism in aggressive gliomas is associated with shorter patients' survival.PMID 26717998Read ↗

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