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Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a P301L mutation in microtubule-associated protein tau (MAPT).

Stem cell research - 1 Jan 2016

Rasmussen Mikkel A, Hjermind Lena E, Hasholt Lis F, Waldemar Gunhild, Nielsen Jørgen E, Clausen Christian, Hyttel Poul, Holst Bjørn

Abstract excerpt

Skin fibroblasts were obtained from a 57-year-old woman diagnosed with frontotemporal dementia. The disease is caused by a P301L mutation in microtubule-associated protein tau (MAPT). Induced pluripotent stem cells (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. iPSCs were free of genomically integrated reprogramming genes, contained...

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Identifiers

PMID: 27345788
DOI: 10.1016/j.scr.2015.12.008

Genes

MAPT
MYC

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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