Article
Induced pluripotent stem cells (iPSCs) derived from a pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia.
Stem cell research - 1 Jan 2016
Rasmussen Mikkel A, Hjermind Lena E, Hasholt Lis F, Waldemar Gunhild, Nielsen Jørgen E, Clausen Christian, Hyttel Poul, Holst Bjørn
Abstract excerpt
Skin fibroblasts were obtained from a 28-year-old pre-symptomatic woman carrying a R406W mutation in microtubule-associated protein tau (MAPT), known to cause frontotemporal dementia. Induced pluripotent stem cell (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. iPSCs were free of genomically integrated reprogramming genes, contained the...
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