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Generation of three hiPSC clones from a frontotemporal dementia (FTD) patient with a heterozygous MAPT mutation p.K298_H299insQ (c.896_897insACA).

Stem cell research - 1 Jun 2026

Hirose Takumi, Ishikawa Kei-Ichi, Li Yuanzhe, Oyama Genko, Hatano Taku, Hattori Nobutaka, Akamatsu Wado

Abstract excerpt

A previously reported microtubule-associated protein tau (MAPT) mutation, p.K298_H299insQ, involving a glutamine insertion between lysine 298 and histidine 299, was identified in patients with frontotemporal dementia. We established induced pluripotent stem cell (iPSC) lines from a patient carrying this mutation. Generated iPSCs displayed typical pluripotency characteristics, differentiation potential into three...

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Cell Differentiation
Clone Cells
Frontotemporal Dementia
MAPT gene
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Induced Pluripotent Stem Cells

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Identifiers

PMID: 41934872
DOI: 10.1016/j.scr.2026.103980

Genes

MAPT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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