Article
Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene.
Stem cell research - 1 Nov 2016
Nimsanor Natakarn, Kitiyanant Narisorn, Poulsen Ulla, Rasmussen Mikkel A, Clausen Christian, Mau-Holzmann Ulrike A, Nielsen Jørgen E, Nielsen Troels T, Hyttel Poul, Holst Bjørn, Schmid Benjamin
Abstract excerpt
Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the MAPT (microtubule-associated protein tau)-gene can cause FTDP-17, but the underlying pathomechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to the...
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