HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer.

doi:10.1038/cmi.2016.33

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Article

HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer.

Cellular & molecular immunology - 1 Feb 2018

Liu Shuxun, Yi Lin, Ling Ma, Jiang Jinxia, Song Lijun, Liu Juan, Cao Xuetao

Abstract excerpt

Heat-shock protein (HSP)-based immunotherapy is established on its adjuvant effects when applied via an extracellular approach to pulse and activate dendritic cells (DCs). Our previous studies indicate that DCs pulsed with recombinant fusion proteins of antigenic fragment and HSP70-like protein 1 (HSP70L1) are potent in stimulating antigen-specific Th1 responses. We herein evaluated the cytotoxic T cell (CTL)...

Topics

Adenoviridae
Animals
Cancer Vaccines
Cell Line, Tumor
Cytokines
Dendritic Cells
HEK293 Cells
HSP70 Heat-Shock Proteins
Humans
Inflammation Mediators
MAP Kinase Signaling System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Nude

Neoplasms

Phenotype

Recombinant Fusion Proteins

STAT1 Transcription Factor

T-Lymphocytes, Cytotoxic

Source

Open in PubMed Open full text

Identifiers

PMID: 27345726
DOI: 10.1038/cmi.2016.33
PMCID: PMC5811675

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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