Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transduction of dendritic cells with recombinant adenovirus encoding HCA661 activates autologous cytotoxic T lymphocytes to target hepatoma cells.

British journal of cancer - 19 Apr 2004

Chan R C-F, Pang X-W, Wang Y-D, Chen W-F, Xie Y

Abstract excerpt

Transduction of recombinant adenovirus into dendritic cells (DCs) is a promising new tool for cancer vaccine development. Here, we report that an adenovirus vector carrying hepatocellular carcinoma (HCC) antigen HCA661 and infected into DCs generates T-cell immunity against hepatoma cells. HCA661 is a novel cancer/testis (CT) antigen screened by SEREX from sera of an HCC patient. We constructed a recombinant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Antigens, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Culture Techniques

Share to Dendritic Cells

Share to Immunotherapy

Share to Monocytes

Share to T-Lymphocytes, Cytotoxic

Share to Transduction, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 15083197
DOI: 10.1038/sj.bjc.6601706
PMCID: PMC2409703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transduction of dendritic cells with recombinant adenovirus encoding HCA661 activates autologous cytotoxic T lymphocytes to target hepatoma cells.PMID 15083197Read ↗

Development of a dendritic cell vaccine encoding multiple cytotoxic T lymphocyte epitopes targeting hepatitis C virus.Semantic proximity Read ↗

Comparative analysis of DC fused with tumor cells or transfected with tumor total RNA as potential cancer vaccines against hepatocellular carcinoma.Semantic proximity Read ↗

HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer.Semantic proximity Read ↗

Dendritic cells transfected with adenoviral vectors as vaccines.Semantic proximity Read ↗

Human dendritic cell maturation by adenovirus transduction enhances tumor antigen-specific T-cell responses.Semantic proximity Read ↗

In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells.Semantic proximity Read ↗

Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man.Semantic proximity Read ↗

Dendritic cells expressing a combined PADRE/MUC4-derived polyepitope DNA vaccine induce multiple cytotoxic T-cell responses.Semantic proximity Read ↗

CD40ligand-expressing dendritic cells induce regression of hepatocellular carcinoma by activating innate and acquired immunity in vivo.Semantic proximity Read ↗

Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cellsSemantic proximity Read ↗

Adenoviruses Activate Human Dendritic Cells without Polarization toward a T-Helper Type 1-Inducing SubsetSemantic proximity Read ↗

Construction of a recombinant adenovirus co-expressing truncated human prostate-specific membrane antigen and mouse 4-1BBL genes and its effect on dendritic cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.