Augmentation of antitumor immunity by fusions of ethanol-treated tumor cells and dendritic cells stimulated via dual TLRs through TGF-β1 blockade and IL-12p70 production.

doi:10.1371/journal.pone.0063498

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Article

Augmentation of antitumor immunity by fusions of ethanol-treated tumor cells and dendritic cells stimulated via dual TLRs through TGF-β1 blockade and IL-12p70 production.

PloS one - 1 Jan 2013

Koido Shigeo, Homma Sadamu, Okamoto Masato, Namiki Yoshihisa, Takakura Kazuki, Takahara Akitaka, Odahara Shunichi, Tsukinaga Shintaro, Yukawa Toyokazu, Mitobe Jimi, Matsudaira Hiroshi, Nagatsuma Keisuke, Kajihara Mikio, Uchiyama Kan, Arihiro Seiji, Imazu Hiroo, Arakawa Hiroshi, Kan Shin, Hayashi Kazumi, Komita Hideo, Kamata Yuko, Ito Masaki, Hara Eiichi, Ohkusa Toshifumi, Gong Jianlin, Tajiri Hisao

Abstract excerpt

The therapeutic efficacy of fusion cell (FC)-based cancer vaccine generated with whole tumor cells and dendritic cells (DCs) requires the improved immunogenicity of both cells. Treatment of whole tumor cells with ethanol resulted in blockade of immune-suppressive soluble factors such as transforming growth factor (TGF)-β1, vascular endothelial growth factor, and IL-10 without decreased expression of major...

Topics

Cell Fusion
Cell Line, Tumor
Cytokines
Dendritic Cells
Ethanol
Humans
Immunologic Factors
Immunotherapy, Adoptive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-12

Lymphocyte Activation

Mucin-1

Neoplasms

Peptide Fragments

Phenotype

T-Lymphocytes, Cytotoxic

Toll-Like Receptors

Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 23717436
DOI: 10.1371/journal.pone.0063498
PMCID: PMC3663747

Genes

MUC1
HMGB1
TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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