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Article

Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2007

Koido Shigeo, Hara Eiichi, Homma Sadamu, Mitsunaga Makoto, Takahara Akitaka, Nagasaki Eijiro, Kawahara Hidejiro, Watanabe Michiaki, Toyama Yoichi, Yanagisawa Satoru, Kobayashi Susumu, Yanaga Katsuhiko, Fujise Kiyotaka, Gong Jianlin, Tajiri Hisao

Abstract excerpt

Dendritic cell (DC)/tumor cell fusion cells (FCs) can induce potent CTL responses. The therapeutic efficacy of a vaccine requires the improved immunogenicity of both DCs and tumor cells. The DCs stimulated with the TLR agonist penicillin-killed Streptococcus pyogenes (OK-432; OK-DCs) showed higher expression levels of MHC class I and II, CD80, CD86, CD83, IL-12, and heat shock proteins (HSPs) than did immature...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17878387
DOI: 10.4049/jimmunol.179.7.4874

Genes

MUC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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