Article
Optimized mobilization of MHC class I- and II- restricted immunity by dendritic cell vaccine potentiates cancer therapy
1 Jan 2022
Abstract excerpt
Background: The participation of major histocompatibility complex (MHC) in antigen presentation shapes both the breadth and magnitude of specific T cell response. Dendritic cells (DCs) activated with nucleic acid or protein that encodes/incorporates multiple antigenic epitopes elicit MHC class I-and II-biased immunity, respectively. Studies demonstrate that an elevated MHC class I-directed CD8 + cytotoxicity T...