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Intracellular and extracellular Hsp70 chaperone as a target for cancer therapy

11 Jul 2013

Abstract excerpt

PURPOSE: Heat shock protein 70 (HSPA family) is a multi-functional protein which protects individual cells from proteotoxic shock and the whole organism from microbial, viral and oncogenic pathogens. These diverse functions may depend upon 'chaperone' activity that allows Hsp70 to regulate the mechanism of damaged protein recovery or utilisation inside a cell and to be a potent adjuvant, stimulating immune...

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Identifiers

PMID: 23845032
DOI: 10.3109/02656736.2013.807439

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