Article
mTOR Inhibition Mitigates Enhanced mRNA Translation Associated with the Metastatic Phenotype of Osteosarcoma Cells In Vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2016
Morrow James J, Mendoza Arnulfo, Koyen Allyson, Lizardo Michael M, Ren Ling, Waybright Timothy J, Hansen Ryan J, Gustafson Daniel L, Zhou Ming, Fan Timothy M, Scacheri Peter C, Khanna Chand
Abstract excerpt
PURPOSE: To successfully metastasize, tumor cells must respond appropriately to biological stressors encountered during metastatic progression. We sought to test the hypothesis that enhanced efficiency of mRNA translation during periods of metastatic stress is required for metastatic competence of osteosarcoma and that this metastasis-specific adaptation is amenable to therapeutic intervention. EXPERIMENTAL...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.