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The pathogenesis of mesothelioma is driven by a dysregulated translatome

13 Aug 2021

Abstract excerpt

Malignant mesothelioma (MpM) is an aggressive, invariably fatal tumour that is causally linked with asbestos exposure. The disease primarily results from loss of tumour suppressor gene function and there are no 'druggable' driver oncogenes associated with MpM. To identify opportunities for management of this disease we have carried out polysome profiling to define the MpM translatome. We show that in MpM there is...

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PMID: 34389715
DOI: 10.1038/s41467-021-25173-7

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