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Article

Translational control is a major contributor to hypoxia induced gene expression.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Jun 2011

van den Beucken Twan, Magagnin Michael G, Jutten Barry, Seigneuric Renaud, Lambin Philippe, Koritzinsky Marianne, Wouters Bradly G

Abstract excerpt

BACKGROUND AND PURPOSE: Hypoxia is a common feature of solid tumors that is associated with an aggressive phenotype, resistance to therapy and poor prognosis. Major contributors to these adverse effects are the transcriptional program activated by the HIF family of transcription factors as well as the translational response mediated by PERK-dependent phosphorylation of eIF2α and inhibition of mTORC1 activity. In...

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Share to Cell Hypoxia
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Neoplastic

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Share to Prostatic Neoplasms

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Source

Identifiers

PMID: 21719133
DOI: 10.1016/j.radonc.2011.05.058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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