Article
Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts.
Oncotarget - 29 Nov 2016
Gupta Shivika S, Zeglinski Matthew R, Rattan Sunil G, Landry Natalie M, Ghavami Saeid, Wigle Jeffrey T, Klonisch Thomas, Halayko Andrew J, Dixon Ian M C
Abstract excerpt
The incidence of heart failure with concomitant cardiac fibrosis is very high in developed countries. Fibroblast activation in heart is causal to cardiac fibrosis as they convert to hypersynthetic cardiac myofibroblasts. There is no known treatment for cardiac fibrosis. Myofibroblasts contribute to the inappropriate remodeling of the myocardial interstitium, which leads to reduced cardiac function and ultimately...
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