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Article

Pulmonary fibrosis in L-NAME-treated mice is dependent on an activated endothelin system.

Canadian journal of physiology and pharmacology - 1 Aug 2008

Kalk Philipp, Mach Alexander, Thone-Reineke Christa, Godes Michael, Heiden Susi, Sharkovska Yuliya, von Websky Karoline, Relle Katharina, Hocher Berthold

Abstract excerpt

Activation of the endothelin (ET) system promotes vasoconstriction, inflammation, and fibrosis in various tissues, including the lung. Therefore, ET-1 transgenic mice overexpressing ET-1 develop pulmonary fibrosis in a slow, age-dependent manner. In vivo, NO is the most important counterregulatory mediator of the ET system and decreases ET-1 promoter activity. The aim of our study was to elucidate the impact on...

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Identifiers

PMID: 18758502
DOI: 10.1139/Y08-047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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