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Article

Effects of AT1- and beta-adrenergic receptor antagonists on TGF-beta1-induced fibrosis in transgenic mice.

European journal of clinical investigation - 1 Oct 2009

Seeland U, Schäffer A, Selejan S, Hohl M, Reil J-C, Müller P, Rosenkranz S, Böhm M

Abstract excerpt

BACKGROUND: Transforming growth factor-beta1 (TGF-beta1) is involved in interstitial remodelling promoting collagen synthesis and suppressing collagen degradation by inhibition of collagenases. TGF-beta1 mediates angiotensin II-dependent effects and modulates beta1-adrenergic signalling. To study the effect of neuroendocrine antagonism on TGF-beta-induced hypertrophic and fibrotic phenotype, we treated TGF-beta1...

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Source

Identifiers

PMID: 19522835
DOI: 10.1111/j.1365-2362.2009.02183.x

Genes

MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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