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Article

A New Role for the Aldosterone/Mineralocorticoid Receptor Pathway in the Development of Mitral Valve Prolapse.

Circulation research - 17 Jul 2020

Ibarrola Jaime, Garcia-Peña Amaia, Matilla Lara, Bonnard Benjamin, Sádaba Rafael, Arrieta Vanessa, Alvarez Virginia, Fernández-Celis Amaya, Gainza Alicia, Navarro Adela, Alvarez de la Rosa Diego, Rossignol Patrick, Jaisser Frederic, López-Andrés Natalia

Abstract excerpt

RATIONALE: Mitral valve prolapse (MVP) is one of the most common valvular disorders. However, the molecular and cellular mechanisms involved in fibromyxomatous changes in the mitral leaflet tissue have not been elucidated. Aldosterone (Aldo) promotes fibrosis in myocardium, and MR (mineralocorticoid receptor) antagonists (MRAs) improve cardiac function by decreasing cardiac fibrosis. OBJECTIVE: We investigated...

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PMID: 32329663
DOI: 10.1161/CIRCRESAHA.119.316427

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