Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glutamate-Oxaloacetate Transaminase 1 Impairs Glycolysis by Interacting with Pyruvate Carboxylase and Further Inhibits the Malignant Phenotypes of Glioblastoma Cells.

World neurosurgery - 1 Oct 2021

Tang Tianchi, Liu Yang, Yang Min, Tu Ming, Zhu Wanchun, Chen Ming

Abstract excerpt

BACKGROUND: Glycolysis is an important metabolic manner in glioblastoma multiforme (GBM)'s rapid growth. It has been reported that glutamate-oxaloacetate transaminase 1 (GOT1) is low-expressed in GBM and patients with high-expressed GOT1 have better prognosis. However, the effect and mechanism of GOT1 on glycolysis and malignant phenotypes of GBM cells are still unclear. METHODS: The expression differences of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Glioblastoma

Share to Glycolysis

Share to Phenotype

Source

Identifiers

PMID: 34325031
DOI: 10.1016/j.wneu.2021.07.097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutamate-Oxaloacetate Transaminase 1 Impairs Glycolysis by Interacting with Pyruvate Carboxylase and Further Inhibits the Malignant Phenotypes of Glioblastoma Cells.PMID 34325031Read ↗

High Expression of Glycolytic Genes in Clinical Glioblastoma Patients Correlates with Lower SurvivalSemantic proximity Read ↗

Upregulation of Glutamic-Oxaloacetic Transaminase 1 Predicts Poor Prognosis in Acute Myeloid LeukemiaSemantic proximity Read ↗

Glutamate and α-ketoglutarate: key players in glioma metabolism.Semantic proximity Read ↗

Glutamate dehydrogenase (GDH) regulates bioenergetics and redox homeostasis in human gliomaSemantic proximity Read ↗

Advancing glioblastoma treatment by targeting metabolismSemantic proximity Read ↗

Bioinformatic profiling identifies the glutaminase to be a potential novel cuproptosis-related biomarker for gliomaSemantic proximity Read ↗

Identification of a Metabolism-Related Risk Signature Associated With Clinical Prognosis in Glioblastoma Using Integrated Bioinformatic AnalysisSemantic proximity Read ↗

Comprehensive Analysis of Glycolytic Enzymes as Therapeutic Targets in the Treatment of GlioblastomaSemantic proximity Read ↗

GOT1 inhibits hepatocellular carcinoma progression by regulating SLC25A5-dependent mitochondrial apoptosisSemantic proximity Read ↗

Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas.Semantic proximity Read ↗

A glycolysis-based ten-gene signature correlates with the clinical outcome, molecular subtype and IDH1 mutation in glioblastoma.Semantic proximity Read ↗

ALDH5A1/miR-210 axis plays a key role in reprogramming cellular metabolism and has a significant correlation with glioblastoma patient survivalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.