Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion.

Diabetes - 1 May 2021

Sachse Gregor, Haythorne Elizabeth, Hill Thomas, Proks Peter, Joynson Russell, Terrón-Expósito Raul, Bentley Liz, Tucker Stephen J, Cox Roger D, Ashcroft Frances M

Abstract excerpt

The ATP-sensitive K+ (KATP) channel controls blood glucose levels by coupling glucose metabolism to insulin secretion in pancreatic β-cells. E23K, a common polymorphism in the pore-forming KATP channel subunit (KCNJ11) gene, has been linked to increased risk of type 2 diabetes. Understanding the risk-allele-specific pathogenesis has the potential to improve personalized diabetes treatment, but the underlying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Glucose

Share to Insulin

Share to Insulin Secretion

Share to Potassium Channels, Inwardly Rectifying

Source

Identifiers

PMID: 33568422
DOI: 10.2337/db20-0691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion.PMID 33568422Read ↗

Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.Semantic proximity Read ↗

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.Semantic proximity Read ↗

Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.Semantic proximity Read ↗

ATP-dependent potassium channels and type 2 diabetes mellitus.Semantic proximity Read ↗

Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.Semantic proximity Read ↗

K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels.Semantic proximity Read ↗

Prediabetes is associated with genetic variations in the gene encoding the Kir6.2 subunit of the pancreatic ATP-sensitive potassium channel (KCNJ11): A case-control study in a Han Chinese youth population.Semantic proximity Read ↗

Polymorphism E23K (rs5219) in the KCNJ11 gene in Euro-Brazilian subjects with type 1 and 2 diabetes.Semantic proximity Read ↗

Single nucleotide polymorphisms in K(ATP) channels: muscular impact on type 2 diabetes.Semantic proximity Read ↗

ATP-sensitive potassium channels in health and disease.Semantic proximity Read ↗

The common single nucleotide polymorphism E23K in K(IR)6.2 sensitizes pancreatic beta-cell ATP-sensitive potassium channels toward activation through nucleoside diphosphates.Semantic proximity Read ↗

Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.