Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unraveling Insulin-Like Growth Factor Binding Protein-3 Actions in Human Disease

28 May 2009

Abstract excerpt

The IGF system plays critical roles in somatic growth in an endocrine fashion (somatomedin hypothesis) as well as proliferation and differentiation of normal and malignant cells in a paracrine/autocrine fashion. IGFBP-3 is known to modulate the actions of IGFs in circulation as well as the immediate extracellular environment. Interestingly, apart from the ability to inhibit or enhance IGF actions, IGFBP-3 also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Growth Hormone and Insulin-like Growth Factors
Share to Lipid metabolism and disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19477944
DOI: 10.1210/er.2008-0028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unraveling Insulin-Like Growth Factor Binding Protein-3 Actions in Human DiseasePMID 19477944Read ↗

Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesisSemantic proximity Read ↗

The Role of the IGF System in Cancer: From Basic to Clinical Studies and Clinical ApplicationsSemantic proximity Read ↗

A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.Semantic proximity Read ↗

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic GrowthSemantic proximity Read ↗

Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Influences Sensitivity to Anti-IGF System Agents Through the Translational Regulation of IGF1RSemantic proximity Read ↗

The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent InsightsSemantic proximity Read ↗

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic GrowthSemantic proximity Read ↗

Insulin-Like Growth Factor Binding Proteins in Kidney DiseaseSemantic proximity Read ↗

IGF binding proteins in cancer: mechanistic and clinical insightsSemantic proximity Read ↗

Insulin-like growth factor-binding protein-6 and cancerSemantic proximity Read ↗

Insulin‐like growth factor ligands, receptors, and binding proteins in cancerSemantic proximity Read ↗

14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.