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Article

Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use.

Archivum immunologiae et therapiae experimentalis - 1 Feb 2017

Zdzisińska Barbara, Żurek Aleksandra, Kandefer-Szerszeń Martyna

Abstract excerpt

Alpha-ketoglutarate (AKG), an endogenous intermediary metabolite in the Krebs cycle, is a molecule involved in multiple metabolic and cellular pathways. It functions as an energy donor, a precursor in the amino acid biosynthesis, a signalling molecule, as well as a regulator of epigenetic processes and cellular signalling via protein binding. AKG is an obligatory co-substrate for 2-oxoglutarate-dependent...

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Source

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Identifiers

PMID: 27326424
DOI: 10.1007/s00005-016-0406-x
PMCID: PMC5274648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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