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Article

Structure and molecular organization of mammalian fatty acid synthase.

Nature structural & molecular biology - 1 Mar 2005

Asturias Francisco J, Chadick James Z, Cheung Iris K, Stark Helga, Witkowski Andrzej, Joshi Anil K, Smith Stuart

Abstract excerpt

De novo synthesis of fatty acids in the cytosol of animal cells is carried out by the multifunctional, homodimeric fatty acid synthase (FAS). Cryo-EM analysis of single FAS particles imaged under conditions that limit conformational variability, combined with gold labeling of the N termini and structural analysis of the FAS monomers, reveals two coiled monomers in an overlapping arrangement. Comparison of dimeric...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15711565
DOI: 10.1038/nsmb899

Genes

FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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