Article
Molecular determinants that mediate the sorting of human ATG9A from the endoplasmic reticulum.
Biochimica et biophysica acta - 1 Sept 2016
Staudt Catherine, Gilis Florentine, Boonen Marielle, Jadot Michel
Abstract excerpt
ATG9A is a multispanning membrane protein required for autophagosome formation. Under basal conditions, neosynthesized ATG9A proteins travel to the Golgi apparatus and cycle between the trans-Golgi network and endosomes. In the present work, we searched for molecular determinants involved in the subcellular trafficking of human ATG9A in HeLa cells using sequential deletions and point mutations. Deletion of amino...
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