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Article

AP-4 mediates export of ATG9A from the trans -Golgi network to promote autophagosome formation

27 Nov 2017

Abstract excerpt

Significance A family of adaptor protein (AP) complexes functions to sort transmembrane cargos at different stages of the endomembrane system of eukaryotic cells. AP-4 is one of the most recently described and least well-understood members of this family. Interest in this complex has risen because mutations in any of its four subunits cause a form of hereditary spastic paraplegia (HSP) with intellectual...

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PMID: 29180427
DOI: 10.1073/pnas.1717327114

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AP-4 mediates export of ATG9A from the trans -Golgi network to promote autophagosome formationPMID 29180427Read ↗

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High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia.Semantic proximity Read ↗

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