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Article

Insights into protein structure, stability and function from saturation mutagenesis.

Current opinion in structural biology - 1 Jun 2018

Gupta Kritika, Varadarajan Raghavan

Abstract excerpt

Where convenient phenotypic readouts are available, saturation mutagenesis coupled to deep sequencing provides a rapid and facile method to infer sequence determinants of protein structure, stability and function. We provide brief descriptions and currently available options for the various steps involved, and mention limitations of current implementations. We also highlight recent applications such as estimating...

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Identifiers

PMID: 29505936
DOI: 10.1016/j.sbi.2018.02.006
PMCID: PMC6078801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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