Article

ESMRank reveals a transferable axis of protein mutational constraint from overlapping variant effect assays

2026-02-28

Abstract excerpt

<h4>ABSTRACT</h4> Proteome-wide interpretation of missense variation is constrained not only by predictive model performance but also by the absence of principled methods to reconcile heterogeneous multiplexed assays of variant effect (MAVEs) into a unified representation of mutational constraint. We show that redundancy among partially overlapping deep mutational scanning experiments encodes a reproducible ordin...

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Literature Corpus work: 4d62ec79-6eb9-5d85-bca2-64a7aa9f8659
DOI: 10.64898/2026.02.26.708185

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