Uncovering differential tolerance to deletions versus substitutions with a protein language model

Abstract excerpt

Deep mutational scanning (DMS) experiments have been successfully leveraged to understand genotype to phenotype mapping, with broad implications for protein engineering, human genetics, drug development, and beyond. To date, however, the overwhelming majority of DMS have focused on amino acid substitutions, excluding other classes of variation such as deletions or insertions. As a consequence, it remains unclear h...

Topics

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• Amino Acid Substitution
• Amino Acids
• Bayes Theorem
• Biological Evolution
• Models, Molecular
• Mutation
• Proteins
• Proteome

Identifiers and source

Literature Corpus work

10bb0bf6-c75a-5daa-81e3-5ca7ef62f833

DOI

10.1101/2024.06.27.601077