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Article

Genetic Variations in ABCA7 Can Increase Secreted Levels of Amyloid-β40 and Amyloid-β42 Peptides and ABCA7 Transcription in Cell Culture Models.

Journal of Alzheimer's disease : JAD - 13 Jun 2016

Bamji-Mirza Michelle, Li Yan, Najem Dema, Liu Qing Yan, Walker Douglas, Lue Lih-Fen, Stupak Jacek, Chan Kenneth, Li Jianjun, Ghani Mahdi, Yang Ze, Rogaeva Ekaterina, Zhang Wandong

Abstract excerpt

Alzheimer's disease (AD) is characterized by extracellular deposits of amyloid-β (Aβ) in the brain. ABCA7 is highly expressed in the brain and a susceptibility gene for late-onset AD (LOAD). The minor alleles at two ABCA7 single-nucleotide polymorphisms (SNPs), rs3764650 (T>G; intron13) and rs3752246 at a predicted myristoylation site (C>G; exon33; p.Gly1527Ala), are significantly associated with LOAD risk;...

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Topics

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Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor
Share to ATP-Binding Cassette Transporters
Share to CHO Cells
Share to Cricetulus
Share to Myristic Acid
Share to Peptide Fragments
Share to Protein Processing, Post-Translational

Source

Identifiers

PMID: 27314524
DOI: 10.3233/JAD-150965

Genes

ABCA7

Variants

rs3764650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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