Article
Targeted sequencing of ABCA7 identifies splicing, stop-gain and intronic risk variants for Alzheimer disease.
Neuroscience letters - 10 May 2017
Kunkle B W, Carney R M, Kohli M A, Naj A C, Hamilton-Nelson K L, Whitehead P L, Wang L, Lang R, Cuccaro M L, Vance J M, Byrd G S, Beecham G W, Gilbert J R, Martin E R, Haines J L, Pericak-Vance M A
Abstract excerpt
Several variants in the gene ABCA7 have been identified as potential causal variants for late-onset Alzheimer's disease (LOAD). In order to replicate these findings, and search for novel causal variants, we performed targeted sequencing of this gene in cohorts of non-Hispanic White (NHW) and African-American (AA) LOAD cases and controls. We sequenced the gene ABCA7 in 291 NHW LOAD cases and 103 controls. Variants...
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