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Article

Transcriptional profile of platelets and iPSC-derived megakaryocytes from whole-genome and RNA sequencing.

Blood - 18 Feb 2021

Kammers Kai, Taub Margaret A, Rodriguez Benjamin, Yanek Lisa R, Ruczinski Ingo, Martin Joshua, Kanchan Kanika, Battle Alexis, Cheng Linzhao, Wang Zack Z, Johnson Andrew D, Leek Jeffrey T, Faraday Nauder, Becker Lewis C, Mathias Rasika A

Abstract excerpt

Genome-wide association studies have identified common variants associated with platelet-related phenotypes, but because these variants are largely intronic or intergenic, their link to platelet biology is unclear. In 290 normal subjects from the GeneSTAR Research Study (110 African Americans [AAs] and 180 European Americans [EAs]), we generated whole-genome sequence data from whole blood and RNA sequence data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33094331
DOI: 10.1182/blood.2020006115
PMCID: PMC7918180

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