Article
Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits.
PLoS genetics - 1 Jun 2011
Paul Dirk S, Nisbet James P, Yang Tsun-Po, Meacham Stuart, Rendon Augusto, Hautaviita Katta, Tallila Jonna, White Jacqui, Tijssen Marloes R, Sivapalaratnam Suthesh, Basart Hanneke, Trip Mieke D, Göttgens Berthold, Soranzo Nicole, Ouwehand Willem H, Deloukas Panos
Abstract excerpt
Turning genetic discoveries identified in genome-wide association (GWA) studies into biological mechanisms is an important challenge in human genetics. Many GWA signals map outside exons, suggesting that the associated variants may lie within regulatory regions. We applied the formaldehyde-assisted isolation of regulatory elements (FAIRE) method in a megakaryocytic and an erythroblastoid cell line to map active...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.