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Article

IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2015

Hsu Peter, Santner-Nanan Brigitte, Hu Mingjing, Skarratt Kristen, Lee Cheng Hiang, Stormon Michael, Wong Melanie, Fuller Stephen J, Nanan Ralph

Abstract excerpt

Foxp3(+) regulatory T cells (Tregs) play essential roles in maintaining the immune balance. Although the majority of Tregs are formed in the thymus, increasing evidence suggests that induced Tregs (iTregs) may be generated in the periphery from naive cells. However, unlike in the murine system, significant controversy exists regarding the suppressive capacity of these iTregs in humans, especially those generated...

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Source

Identifiers

PMID: 26363058
DOI: 10.4049/jimmunol.1402898

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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