Article
Genetic risk scores link body fat distribution with specific cardiometabolic profiles.
Obesity (Silver Spring, Md.) - 1 Aug 2016
Svendstrup Mathilde, Sandholt Camilla H, Andersson Galijatovic Ehm Astrid, Linneberg Allan, Jørgensen Torben, Sørensen Thorkild I A, Pedersen Oluf, Grarup Niels, Hansen Torben, Vestergaard Henrik
Abstract excerpt
OBJECTIVE: Forty-nine known single nucleotide polymorphisms (SNPs) associating with body mass index (BMI)-adjusted waist-hip-ratio (WHR) (WHRadjBMI) were recently suggested to cluster into three groups with different associations to cardiometabolic traits. Genetic risk scores of the clusters on the risk of incident diabetes and associations with detailed cardiometabolic phenotypes were tested. METHODS: In a...
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