Article
Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis.
Circulation - 13 Jun 2017
Dale Caroline E, Fatemifar Ghazaleh, Palmer Tom M, White Jon, Prieto-Merino David, Zabaneh Delilah, Engmann Jorgen E L, Shah Tina, Wong Andrew, Warren Helen R, McLachlan Stela, Trompet Stella, Moldovan Max, Morris Richard W, Sofat Reecha, Kumari Meena, Hyppönen Elina, Jefferis Barbara J, Gaunt Tom R, Ben-Shlomo Yoav, Zhou Ang, Gentry-Maharaj Aleksandra, Ryan Andy, Mutsert Renée de, Noordam Raymond, Caulfield Mark J, Jukema J Wouter, Worrall Bradford B, Munroe Patricia B, Menon Usha, Power Chris, Kuh Diana, Lawlor Debbie A, Humphries Steve E, Mook-Kanamori Dennis O, Sattar Naveed, Kivimaki Mika, Price Jacqueline F, Davey Smith George, Dudbridge Frank, Hingorani Aroon D, Holmes Michael V, Casas Juan P
Abstract excerpt
BACKGROUND: The implications of different adiposity measures on cardiovascular disease etiology remain unclear. In this article, we quantify and contrast causal associations of central adiposity (waist-to-hip ratio adjusted for body mass index [WHRadjBMI]) and general adiposity (body mass index [BMI]) with cardiometabolic disease. METHODS: Ninety-seven independent single-nucleotide polymorphisms for BMI and 49...
Topics
- Adiposity
- Body Fat Distribution
- Coronary Disease
- Diabetes Mellitus, Type 2
- Humans