Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease.

doi:10.1001/jama.2016.21042

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Article

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease.

JAMA - 14 Feb 2017

Emdin Connor A, Khera Amit V, Natarajan Pradeep, Klarin Derek, Zekavat Seyedeh M, Hsiao Allan J, Kathiresan Sekar

Abstract excerpt

Importance: In observational studies, abdominal adiposity has been associated with type 2 diabetes and coronary heart disease (CHD). Whether these associations represent causal relationships remains uncertain. Objective: To test the association of a polygenic risk score for waist-to-hip ratio (WHR) adjusted for body mass index (BMI), a measure of abdominal adiposity, with type 2 diabetes and CHD through the...

Topics

Blood Glucose
Blood Pressure
Body Mass Index
Case-Control Studies
Coronary Disease
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Female
Humans
Male
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Obesity, Abdominal

Odds Ratio

Polymorphism, Single Nucleotide

Triglycerides

Waist-Hip Ratio

Source

Open in PubMed Open full text

Identifiers

PMID: 28196256
DOI: 10.1001/jama.2016.21042
PMCID: PMC5571980

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