Article
Mea6 controls VLDL transport through the coordinated regulation of COPII assembly.
Cell research - 1 Jul 2016
Wang Yaqing, Liu Liang, Zhang Hongsheng, Fan Junwan, Zhang Feng, Yu Mei, Shi Lei, Yang Lin, Lam Sin Man, Wang Huimin, Chen Xiaowei, Wang Yingchun, Gao Fei, Shui Guanghou, Xu Zhiheng
Abstract excerpt
Lipid accumulation, which may be caused by the disturbance in very low density lipoprotein (VLDL) secretion in the liver, can lead to fatty liver disease. VLDL is synthesized in endoplasmic reticulum (ER) and transported to Golgi apparatus for secretion into plasma. However, the underlying molecular mechanism for VLDL transport is still poorly understood. Here we show that hepatocyte-specific deletion of...
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