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Article

Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core.

The Journal of biological chemistry - 5 Apr 2013

Camus Gregory, Herker Eva, Modi Ankit A, Haas Joel T, Ramage Holly R, Farese Robert V, Ott Melanie

Abstract excerpt

The triglyceride-synthesizing enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) plays a critical role in hepatitis C virus (HCV) infection by recruiting the HCV capsid protein core onto the surface of cellular lipid droplets (LDs). Here we find a new interaction between the non-structural protein NS5A and DGAT1 and show that the trafficking of NS5A to LDs depends on DGAT1 activity. DGAT1 forms a complex...

Read the complete abstract on PubMed

Topics

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Share to Capsid
Share to Diacylglycerol O-Acyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Hepatitis C

Share to Lentivirus

Share to Lipids

Share to Triglycerides

Share to Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23420847
DOI: 10.1074/jbc.M112.434910
PMCID: PMC3617291

Genes

DGAT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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